Acute myeloid leukemia (AML), also called acute myelogenous leukemia, is a type of blood cancer that develops rapidly in the bone marrow and reduces the formation of white blood cells, red blood cells, and platelets. It mostly affects myeloid cells, which are responsible for the production of blood cells.
According to the National Cancer Institute, AML is the most prevalent form of acute leukemia in adults, with an estimated annual prevalence of about 19,520 new cases in just the United States.
Acute myeloid leukemia (AML) mostly affects elderly people and is rare before the age of 45. AML is diagnosed around the age of 68, making it mostly a disease of the elderly. However, AML may occur in children also. Men have a slightly higher prevalence of acute myeloid leukemia (AML) than women. The overall lifetime chance of getting AML in both genders is about 0.5%, or half of 1%.
If you or someone you know is looking for Acute Myeloid Leukemia (AML) treatment in India, you must be diagnosed early and receive proper medical treatment.
Types of Acute Myeloid Leukemia (AML)
Acute myeloid leukemia (AML) is a diverse group of blood cancers divided based on cancer cell maturity and genetic characteristics.
Symptoms of Acute Myeloid Leukemia (AML)
Some of the common symptoms of AML include:
Risk factors associated with Acute Myeloid Leukemia (AML)
Some of the common risk factors associated with Acute Myeloid Leukemia (AML) are:
Causes of Acute Myeloid Leukemia (AML)
Some of the common factors related to the causes of Acute Myeloid Leukemia (AML) are:
Genetic Changes resulting in Acute Myeloid Leukemia (AML)
Bone Marrow Function: Bone marrow, which is found within the bones, is responsible for producing blood cells and platelets.
Blood Cell Production: Under normal conditions, the bone marrow produces stem cells that develop into red blood cells for transporting oxygen, white blood cells for protection from infection, and platelets for clotting.
AML’s Genetic Disruption: AML develops when mutations in the bone marrow cause the development of abnormal myeloid cells known as myeloid blasts or myeloblasts.
Aberrant Behavior: Myeloid blasts leave the normal DNA rules that control cell division and planned cell death. In contrast to normal cells, they grow uncontrolled and do not die naturally.
Overcrowding and Blood Cell Production Halt: Myeloid blast growth outnumbers healthy blood cell production in the bone marrow. As a result, the bone marrow stops producing enough healthy blood cells for proper biological activities.
Systemic Impact: Myeloid blasts spread into the bloodstream and go to many parts of the body, including the central nervous system, brain, and spinal cord, as they reproduce abnormally.
Diagnosis of Acute Myeloid Leukemia (AML)
Blood Tests:
Bone Marrow Tests:
Genetic Testing: It examines leukemia cells in laboratories to identify gene mutations and chromosome abnormalities.
Specialized Tests:
Treatment options for Acute Myeloid Leukemia (AML)
Chemotherapy: Chemotherapy is the use of powerful medications to kill leukemia cells in the blood and bone marrow. Common medications include cytarabine, daunorubicin, idarubicin, azacitidine, decitabine, and venetoclax.
Targeted Therapy: Targeted medicines such as midostaurin (FLT3 mutation) or gilteritinib (FLT3 mutation) may be given alone or in combination with chemotherapy for certain genetic mutations.
Monoclonal Antibody Therapy: Certain AML patients might be helped with monoclonal antibodies that attach to CD33 on leukemia cells.
Prognosis of Acute Myeloid Leukemia (AML)
50% to 80% of patients with leukemia can recover and no longer have the disease. This is known as complete remission, and it is more common in younger people and children. It can last for several years.
However, almost half of the individuals who recover may experience a relapse of leukemia. If this occurs, doctors might suggest additional treatments such as chemotherapy or perhaps a stem cell transplant.
Survival Rate of Acute Myeloid Leukemia (AML)
Because of the numerous subtypes of Acute Myeloid Leukemia (AML), survival rates are highly variable. For example, children under the age of 15 have a 67% five-year survival rate, but for those with the APL subtype, this rate may exceed 80%. Adults with AML, on the other hand, have a five-year survival rate of roughly 30%, owing to the fact that AML is more common in those aged 60 and older.
It is important to note that factors such as age, overall health, genetic abnormalities, and response to treatment can all have a major effect on survival rates. Younger patients and those with more favorable genetic profiles tend to perform better. In recent years, advances in treatments, including stem cell transplantation and customized medicines, have improved survival rates.
Cost of Acute Myeloid Leukemia (AML) Treatment in India
The Acute Myeloid Leukemia (AML) treatment cost in India depends on factors such as treatment type, hospital choice, and different medical conditions.
Best Hospitals for Acute Myeloid Leukemia (AML) Treatment in India
India has several world-class hospitals recognized for their expertise in the treatment of Acute Myeloid Leukemia (AML). These hospitals include advanced facilities, skilled medical teams, and a comprehensive choice of AML treatments. Patients from all around the world seek treatment at these best Hospitals in India for Acute Myeloid Leukemia (AML) Treatment.
Top Doctors for Acute Myeloid Leukemia (AML) Treatment in India
India has highly skilled specialists who specialize in the treatment of Acute Myeloid Leukemia (AML). These skilled medical specialists are well-equipped to give comprehensive care for Acute Myeloid Leukemia (AML) treatment in India.
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